Synthesis of Five- and Six-Membered-Ring Compounds by Environmentally Friendly Radical Cyclizations Using Kolbe Electrolysis

Lebreux, Frederic;Buzzo, Ferdinando;Marko, Istvan
(2008) Synlett : accounts and rapid communications in synthetic organic chemistry — n° 18, p. 2815-2820 (2008)

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  • Lebreux, FredericUCLouvain
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  • Buzzo, FerdinandoUCLouvain
    Author
  • Marko, IstvanUCLouvain
    Author
Abstract
Substituted carbocycles, tetrahydrofurans, and tetrahydropyrans can be efficiently obtained from omega-unsaturated carboxylic acids. Our methodology involves a Kolbe decarboxylation followed by in intramolecular radical cyclization and a radical-radical cross-coupling process.
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Lebreux, F., Buzzo, F., & Marko, I. (2008). Synthesis of Five- and Six-Membered-Ring Compounds by Environmentally Friendly Radical Cyclizations Using Kolbe Electrolysis. Synlett : accounts and rapid communications in synthetic organic chemistry, 18, 2815-2820. https://doi.org/10.1055/s-0028-1083547 (Original work published 2008)