Oligodeoxyribonucleotide phosphorothioates kill procyclic Trypanosoma brucei brucei: Quantitative determination of their LD50

Brouckaert, S.;Cottem, Dominique;Berens, C.;Sonveaux, Etienne;Bouzin, Caroline
(1997) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 7, n° 15, p. 2071-2076 (1997)

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Authors
  • Brouckaert, S.
    Author
  • Cottem, DominiqueUCLouvain
    Author
  • Berens, C.
    Author
  • Sonveaux, EtienneUCLouvain
    Author
  • Bouzin, Carolineorcid-logoUCLouvain
    Author
Abstract
Phosphorothioates kill the procyclic form of T. brucei brucei by a non antisense but sequence dependent effect. The alamar Blue(TM) method allowed an easy microscale determination of their antiparasitic effect. The LD50 of the sequences tested was in the range of 11-20 mu M. (C) 1997 Elsevier Science Ltd.
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Brouckaert, S., Cottem, D., Berens, C., Sonveaux, E., & Bouzin, C. (1997). Oligodeoxyribonucleotide phosphorothioates kill procyclic Trypanosoma brucei brucei: Quantitative determination of their LD50. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 7(15), 2071-2076. https://doi.org/10.1016/S0960-894X(97)00362-4 (Original work published 1997)