The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo
(1999) Molecular Cell — Vol. 4, n° 4, p. 627-632 (1999)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 106.81 KB
Details
- Authors
- Abstract
- Transcytosis of polymeric immunoglobulin A (pIgA) across epithelial cells is mediated by the polymeric immunoglobulin receptor (pIgR). Binding of pIgA to pIgR stimulates transcytosis of the pIgA-pIgR complex via a signal transduction pathway that is dependent on a protein tyrosine kinase (PTK) of the SRC family. Here we identify the PTK as p62(yes). We demonstrate the specific physical and functional association of the pIgR with p62(yes) in rodent liver. Analysis of p62(yes) knockout mice revealed a dramatic reduction in the association of tyrosine kinase activity with the pIgR and in transcytosis of pIgA. We conclude that p62(yes) controls pIgA transcytosis in vivo.
- Affiliations
Citations
Luton, F., Vergés, M., Vaerman, J.-P., Sudol, M., & Mostov, K. E. (1999). The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo. Molecular Cell, 4(4), 627-632. https://doi.org/10.1016/S1097-2765(00)80213-0 (Original work published 1999)