Inhibition of the Focal Adhesion Kinase Has Anti-Tumoral Effect in Small-Cell Lung Cancer Cell Lines
(2015) European Lung Cancer Conference (ELCC) — Location: (Switzerland) Geneva (15.April.2015)
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- AIM: Lung cancer is the most common cancer and also the leading cause of cancer-related death worldwide among both men and women. Small cell lung cancer (SCLC) accounts for 15% of all cases. It is the most aggressive one in its clinical behavior with a 5-year overall survival as low as 5%. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase which regulates integrin and growth factor signaling pathways involved in cell proliferation, survival, migration, and invasion. FAK is overexpressed and/or activated in many cancers including SCLC. We hypothesized that FAK may represent a good target for therapeutic interventions in SCLC and tested the changes of cell phenotype induced by a FAK inhibitor (PF-228). [...]
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Aboubakar Nana, F., Lecocq, M., Detry, B., Ladjemi, M., Massion, P. P., Sibille, Y., Pilette, C., & Ocak, S. (2015). Inhibition of the Focal Adhesion Kinase Has Anti-Tumoral Effect in Small-Cell Lung Cancer Cell Lines. Annals of Oncology, 26(Suppl 1), i17. https://doi.org/10.1093/annonc/mdv047.01 (Original work published 2015)