Protein acetylation, a new player in the regulation of cardiac metabolism
(2020)
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- Authors
- Supervisors
- Bertrand, Luc
- Abstract
- Cardiovascular diseases are the leading cause of death in diabetic population. Metabolic inflexibility along with insulin resistance are strong instigators of the diabetic cardiomyopathy. According to prospective studies, leucine emerges as a potent predictive marker for the onset of metabolic diseases such as type 2 diabetes. As the diabetic heart faces an impaired glucose uptake and utilization, we evaluated the impact of leucine on its uptake. We demonstrated that leucine inhibits basal, insulin- and AMPK-induced cardiac glucose transport. Using targeted metabolomics, we confirmed that leucine is metabolized in cardiomyocytes, serving as an energy-providing substrate. We proposed that acetyl-CoA resulting from leucine catabolism participates in a global increase in protein acetylation, which regulates glucose uptake. Illustrating this paradigm, we showed that modifying the acetylation of tubulin, the building block of microtubules, impacts cardiac glucose transport.
- Affiliations
Citations
Renguet, E. (2020). Protein acetylation, a new player in the regulation of cardiac metabolism. https://hdl.handle.net/2078.5/94780