Hépatite fulminante compliquée d’un syndrome hémophagocytaire réactionnel chez un patient immunocompétent : deux manifestations rares d’une infection à Herpes simplex virus 1
(2022) Louvain médical — Vol. 141, n° 9-10, p. 496-501 (2022)
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- (en) [Fulminant hepatitis complicated by a reactive hemophagocytic syndrome in an immunocompetent patient: two rare manifestations of Herpes simplex virus 1 infection.] Fulminant hepatitis is a rare and fatal complication of Herpes simplex virus 1 (HSV1) infection, which can affect both immunocompetent and immunodeficient adults. The diagnosis is often delayed due to the rapid evolution of the infection, hence the importance of initiating rapid treatment with aciclovir. We report the case of a 36-year-old patient with no medical history who consulted for sudden asthenia after two days of fever and myalgia. The initial laboratory workup revealed hepatic cytolysis and bicytopenia (thrombocytopenia and leukopenia). The evolution was rapidly unfavorable, with the development of acute hepatic failure and a reactive hemophagocytic syndrome. The etiological workup then revealed an HSV1 infection. Treatment with aciclovir resulted in clinical and biological improvement, and the patient fully recovered.
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Citations
Brilot, S., Calvo Lasso De La Vega, E., Michaux, C., Belkhir, L., & Pothen, L. (2022). Hépatite fulminante compliquée d’un syndrome hémophagocytaire réactionnel chez un patient immunocompétent : deux manifestations rares d’une infection à Herpes simplex virus 1. Louvain médical, 141(9-10), 496-501. https://hdl.handle.net/2078.5/164680 (Original work published 2022)