Genomic grade adds prognostic value in invasive lobular carcinoma
(2013) Annals of Oncology — Vol. 24, n° 2, p. 377-384 (2013)
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- Background: The prognostic value of histologic grade (HG) in invasive lobular carcinoma (ILC) remains uncertain, and most ILC tumors are graded as HG2. Genomic grade (GG) is a 97-gene signature that improves the prognostic value of HG. This study evaluates whether GG may overcome the limitations of HG in ILC. Methods: Gene expression data were generated from frozen tumor samples, and GG calculated according to the expression of 97 genes. The prognostic value of GG was assessed in a stratified Cox regression model for invasive disease-free survival (IDFS) and overall survival (OS). Results: A total of 166 patients were classified by GG. HG classified 33 (20%) tumors as HG1, 120 (73%) as HG2 and 12 (7%) as HG3. GG classified 106 (64%) tumors as GG low (GG1), 29 (17%) as GG high (GG3) and 31 (19%) as equivocal (cases not classified as GG1 or GG3). The median follow-up time was 6.5 years. In multivariate analyses, GG was associated with IDFS [HRGG3 vs GG1 5.6 (2.1-15.3); P < 0.001] and OS [HRGG3 vs GG1 7.2, 95% CI (1.6-32.2); P = 0.01]. Conclusions: GG outperformed HG in ILC and added prognostic value to classic clinicopathologic variables, including nodal status
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Metzger-Filho, O., Michiels, S., Bertucci, F., Catteau, A., Salgado, R., Galant, C., Fumagalli, D., Singhal, S. K., Desmedt, C., Ignatiadis, M., Haussy, S., Finetti, P., Birnbaum, D., Saini, K. S., Berlière, M., Veys, I., de Azambuja, E., Bozovic, I., Peyro-Saint-Paul, H., et al. (2013). Genomic grade adds prognostic value in invasive lobular carcinoma. Annals of Oncology, 24(2), 377-384. https://doi.org/10.1093/annonc/mds280 (Original work published 2013)