Stem cell bioprocess engineering towards cGMP production and clinical applications
(2014) Cytotechnology : international journal of cell culture and biotechnology — Vol. 66, n° 5, p. 709-722 (2014)
Files
StemCellBioprocessEng_Sart_R12013-10-21_SNAforDIAL.pdf
Restricted Access - Adobe PDF
- 571.44 KB
Details
- Authors
Agathos, Spiros N. 
- Abstract
- Stem cells, including mesenchymal stem cells and pluripotent stem cells, are becoming an indispensable tool for various biomedical applications including drug discovery, disease modeling, and tissue engineering. Bioprocess engineering, targeting large scale production, provides a platform to generate a controlled microenvironment that could potentially recreate the stem cell niche to promote stem cell proliferation or lineage-specific differentiation. This survey aims at defining the characteristics of stem cell populations currently in use and the present-day limits in their applications for therapeutic purposes. Furthermore, a bioprocess engineering strategy based on bioreactors and 3-D cultures is discussed in order to achieve the improved stem cell yield, function, and safety required for production under current good manufacturing practices
- Affiliations
Citations
Sart, S., Schneider, Y.-J., Li, Y., & Agathos, S. N. (2014). Stem cell bioprocess engineering towards cGMP production and clinical applications. Cytotechnology : international journal of cell culture and biotechnology, 66(5), 709-722. https://doi.org/10.1007/s10616-013-9687-7 (Original work published 2014)