Priming Cardiopulmonary Bypass in Pediatric Surgery : Reply
(2020) Anesthesiology — Vol. 133, n° 1, p. 239-241 (2020)
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- (en) IN REPLY : We thank Dr. Schmartz et al. for their interest in our randomized clinical trial comparing fresh frozen plasma versus crystalloid for priming cardiopulmonary bypass (CPB) circuit in pediatric surgery. The authors are right in noting that our studied population does not belong to the group of patients at the highest risk of postoperative bleeding, i.e. neonates and small infants. However, up to now, no single double-blind study has evaluated this issue in older infants and small children. From an ethical point of view this question needed to be analyzed in this population before conducting a similar study in a very high-risk population. As a matter of fact, the recent published guidelines on patient blood management in pediatrics undergoing cardiac surgery concluded that in infants and children, no recommendations can be made regarding the addition of fresh frozen plasma to the CPB because of the absence of evidence in the matter. [...]
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Dieu, A., & Momeni, M. (2020). Priming Cardiopulmonary Bypass in Pediatric Surgery : Reply. Anesthesiology, 133(1), 239-241. https://doi.org/10.1097/aln.0000000000003352 (Original work published 2020)