Cloning and Chromosomal Localization of a Pseudogene Corresponding To a Messenger-rna for a Soluble Il-6 Receptor
(1995) DNA Sequence — Vol. 5, n° 5, p. 311-314 (1995)
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- Abstract
- A polymerase chain reaction assay (Lust J.A. et al. (1992). Cytokine 4:96-100) was used to detect a mRNA coding for a soluble IL-6 receptor in human hepatoma cells. In addition to the expected amplification product, we found a sequence (SR4) which could be aligned to it with 78% identity. After cloning and sequencing a genomic 2.5-2.7 kB EcoRI fragment containing SR4, this sequence turned out to be part of a pseudogene corresponding to the transmembrane domain deleted soluble IL-6 receptor. Screening of a panel of interspecies hybrids revealed that it maps to chromosome 9.
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Snyers, L., Renauld, J.-C., Szpirer, C., & Content, J. (1995). Cloning and Chromosomal Localization of a Pseudogene Corresponding To a Messenger-rna for a Soluble Il-6 Receptor. DNA Sequence, 5(5), 311-314. https://hdl.handle.net/2078.5/144906 (Original work published 1995)