Risk of hospitalisation and mortality among patients with interstitial lung disease and COVID-19: A French multicentre prospective cohort.
(2025) Pulmonology — Vol. 31, n° 1, p. 2598693 (2025)
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Diesler, Rémi 
- Abstract
- Risk factors of poor outcomes associated with COVID-19 are not well identified in patients with interstitial lung disease (ILD). We analysed a multicentre prospective cohort of patients with ILD and COVID-19 from January 2020 to December 2022. Risk factor analysis for death at 90 days and hospitalisation was conducted using logistic regression, adjusted for age and sex. A total of 603 patients were included (66 years [54-74], 62% male). ILD diagnoses were autoimmune ILD ( = 147 [24%]), idiopathic pulmonary fibrosis (IPF, = 124 [21%]), non-IPF fibrosing ILD ( = 118 [20%]), granulomatosis ( = 115 [19%]), exposure-related/secondary ILD ( = 68 [11%]), and other rare lung diseases ( = 31 [5%]). Hospitalisation due to COVID-19 was associated with cardiovascular disease, cancer or haematological disease, background glucocorticoid therapy, DL < 40%pred and FVC < 70%pred. Death due to COVID-19 at day 90 was associated with the underlying ILD diagnosis, background glucocorticoid therapy, cardiovascular disease, cancer or haematological disease, and DL < 40%pred, whereas vaccination against SARS-CoV-2 was protective. COVID-19-related mortality occurred mainly in the first 90 days after SARS-CoV-2 infection. Poor outcomes related to COVID-19 are associated with ILD subtype and severity, background glucocorticoid therapy and absence of vaccination. There is no evidence of late mortality.
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Diesler, R., Gallay, L., Uzunhan, Y., Borie, R., Reynaud-Gaubert, M., Valentin, V., Ahmad, K., Lazor, R., Wemeau, L., Traclet, J., Rigaud, P., Marchand-Adam, S., Israël-Biet, D., Hirschi, S., Bonniaud, P., Froidure, A., Montani, D., Naccache, J.-M., Romain-Scelle, N., & Cottin, V. (2025). Risk of hospitalisation and mortality among patients with interstitial lung disease and COVID-19: A French multicentre prospective cohort. Pulmonology, 31(1), 2598693. https://doi.org/10.1080/25310429.2025.2598693 (Original work published 2025)