First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy : GENEPI-II
(2010) Radiotherapy & Oncology — Vol. 97, n° 1, p. 36-39 (2010)
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- BACKGROUND: Identifying the most radiosensitive patient group would have huge clinical implications. METHODS: A tissue bank containing skin fibroblasts, whole blood, lymphocytes, plasma and lymphoblastoid cell lines from clinically radiation hypersensitive patients was established from patients in Europe and Canada. Over-reacting individuals had CTCAE3.0 severe acute side effects grade 2 or more occurring at very low radiation doses where these side effects are unexpected or grade 3-4 lasting more than 4 weeks after the end of radiotherapy and/or requiring surgical intervention at any time or severe late side effects grade 3-4. RESULTS: Eleven patients have been identified with a mean age of 61.6±8.5 years (range 49-74). Two patients were male, 9 female. One patient had non-small cell lung cancer, 6 breast cancer, 2 head and neck cancer, one lymphoma and one meningioma. The mean follow-up time after radiotherapy was 1658±1048 days (range 84-3752). CONCLUSIONS: The establishment of an international tissue bank of the rare group of patients with extreme hypersensitivity to radiotherapy was proven to be feasible and should enable in-depth molecular studies
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De Ruysscher, D., Severin, D., Barnes, E., Baumann, M., Bristow, R., Grégoire, V., Hölscher, T., Veninga, T., Polański, A., van Veen, E.-B., Verfaillie, C., Heeren, G., Damaraju, S., Just, U., & Haustermans, K. (2010). First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy : GENEPI-II. Radiotherapy & Oncology, 97(1), 36-39. https://doi.org/10.1016/j.radonc.2010.03.012 (Original work published 2010)