Screening of cytotoxic activities of Strychnos alkaloids (methods and results)

Quetin-Leclercq, Joëlle;De Pauw-Gillet, Marie-Claire;Bassleer, Rger;Angenot, Luc
(1986) Journal of Ethnopharmacology — Vol. 15, n° 3, p. 305-316 (1986)

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The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors used a relatively simple microtest which gives good reproducibility. Most of the active compounds belong to the usambarane skeleton but other structure-activity relationships are being discussed.
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Quetin-Leclercq, J., De Pauw-Gillet, M.-C., Bassleer, R., & Angenot, L. (1986). Screening of cytotoxic activities of Strychnos alkaloids (methods and results). Journal of Ethnopharmacology, 15(3), 305-316. https://doi.org/10.1016/0378-8741(86)90169-8 (Original work published 1986)