Mechanisms and regulation of water transport across the peritoneal membrane
(2016)
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- Abstract
- Peritoneal dialysis represents the major home-based dialysis modality for patients with end-stage renal disease. The capacity of the peritoneal membrane to transport water in response to an osmotic gradient contributes to the efficiency of the technique. Previous studies have demonstrated that aquaporin water channels are expressed in the endothelium lining peritoneal microvessels and mediate ultrafiltration during peritoneal dialysis. The investigations presented in this work provide novel insights into the molecular mechanisms of water transport across the peritoneal membrane and its regulation in health and disease, including the characterization of the first pharmacological agonist of water channels; the impact of fibrosis in the peritoneal interstititium on water transport; the fundamental mechanisms of crystalloid versus colloid osmosis; and the identification of a common variant in the AQP1 gene that influences osmotic water transport in vivo. We hope these collaborative and translational studies may contribute to a better understanding of the peritoneal membrane and, in fine, to a better care of patients treated with peritoneal dialysis.
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Morelle, J. (2016). Mechanisms and regulation of water transport across the peritoneal membrane. https://hdl.handle.net/2078.5/179759