Irritant-Induced Asthma.
(2022) The Journal of Allergy and Clinical Immunology: In Practice — Vol. 10, n° 11, p. 2799-2806 (2022)
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- Abstract
- Irritant-induced asthma (IIA) is a phenotype of asthma caused by the inhalation of irritant agents. Definite IIA, probable IIA, or possible IIA have been described depending on the concentration of the inhaled irritants and the onset of respiratory symptoms respective to the time of exposure. Definite IIA represents approximately 4% to 14% of all cases of new-onset work-related asthma. The agents responsible of IIA can be encountered as fumes, gases, aerosols, or dusts. The most frequent are chlorine, nitrogen oxides, sulphur dioxide, ammonia, acetic acid, solvents, and cleaning materials. Although the diagnosis of definite IIA is based upon a suggestive clinical history along with evidence of reversible airflow limitation and/or non-specific bronchial hyperresponsiveness, possible IIA cannot be diagnosed with certainty as the relationship between exposure and the onset of symptoms is difficult to establish. The present article reviews the epidemiology, pathophysiology, diagnostic approach, and management of IIA.
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Lemiere, C., Lavoie, G., Doyen, V., & Vandenplas, O. (2022). Irritant-Induced Asthma. The Journal of Allergy and Clinical Immunology: In Practice, 10(11), 2799-2806. https://doi.org/10.1016/j.jaip.2022.06.045 (Original work published 2022)