The Type 9 secretion system translocon
(2018) Bacterial Protein Export — Location: Leuven, Belgium
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- Authors
Lauber, Frédéric 
- Abstract
- The T9SS is a novel secretion system exclusively found in Gram-negative bacteria of the phylum Bacteroidetes1. It is involved in a wide array of processes ranging from biofilm and S-layer formation to secretion of virulence factors in fish and avian pathogens. It is most notably associated with the human pathogen Porphyromonas gingivalis, the etiologic agent of chronic periodontitis, in which it is responsible for the secretion of the bacterium’s main virulence factors, so-called gingipains2. T9SS substrates are secreted in a two-step process, using the general secretory (Sec) pathway to cross the inner membrane before being translocated across the outer membrane (OM) via the T9SS. This second step is mediated by a specific recognition signal located in the C-terminus (the CTD) of T9SS substrates. After completion of this second step, the CTD is proteolytically removed and substrates are either released or attached to the cell surface2,3. While all major components of the T9SS have been identified, little is known about the key aspects of the transport process across the OM, including how substrates are recognized and targeted to the secretion pore and, most importantly, the identity of the pore itself. Our recent progress on characterising this pathway in F. johnsoniae, a non-pathogenic model organism of the T9SS, will be reported.
- Affiliations
Department of Biochemistry University of Oxford
Citations
Lauber, F. (2018). The Type 9 secretion system translocon. Bacterial Protein Export, Leuven, Belgium. https://hdl.handle.net/2078.5/215269