Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.

Bosier, Barbara;Doyen, Pierre;Brolet, Amandine;Muccioli, Giulio;Deumens, Ronald;et.al.
(2015) British Journal of Pharmacology — Vol. 172, n° 22, p. 5333-5346 (2015)

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Abstract
Regulators of G protein signalling (RGS) are major determinants of metabotropic receptor activity, reducing the lifespan of the GTP-bound state of G proteins. Because the reduced potency of analgesic agents in neuropathic pain may reflect alterations in RGS, we assessed the effects of CCG 63802, a specific RGS4 inhibitor, on pain hypersensitivity and signalling through cannabinoid receptors, in a model of neuropathic pain.
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Bosier, B., Doyen, P., Brolet, A., Muccioli, G., Ahmed, E., Desmet, N., Hermans, E., & Deumens, R. (2015). Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. British Journal of Pharmacology, 172(22), 5333-5346. https://doi.org/10.1111/bph.13324 (Original work published 2015)