Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.

Bosier, Barbara;Doyen, Pierre;Brolet, Amandine;Muccioli, Giulio;Deumens, Ronald;et.al.

Files

Inhibitionoftheregulator.pdf
  • Restricted Access
  • Adobe PDF
  • 1.62 MB
Request a copy

Details

Authors
Show more
Abstract
Regulators of G protein signalling (RGS) are major determinants of metabotropic receptor activity, reducing the lifespan of the GTP-bound state of G proteins. Because the reduced potency of analgesic agents in neuropathic pain may reflect alterations in RGS, we assessed the effects of CCG 63802, a specific RGS4 inhibitor, on pain hypersensitivity and signalling through cannabinoid receptors, in a model of neuropathic pain.
Affiliations

Citations