Effects of tabernanthine on calcium and catecholamine stimulated contractions of isolated vascular and cardiac muscle.
(1985) Archives Internationales de Pharmacodynamie — Vol. 276, n° 1, p. 35-43 (1985)
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- Abstract
- The Iboga alkaloid tabernanthine (80 microM) non-competitively antagonized contractions in both the rat aorta and mesenteric artery induced by cumulative additions of noradrenaline and calcium. Tabernanthine (8, 40 and 80 microM) antagonized the K+ depolarization-induced contractions of the aorta. Tabernanthine (80 microM) depressed the phasic component of contractions induced by a single maximal concentration (10 microM) of noradrenaline in Ca++ -free solution. Tabernanthine induced a negative inotropic effect in electrically stimulated myocardial tissue and a negative chronotropic effect in the perfused rat heart. Tabernanthine is a calcium entry blocker which also affects cellular calcium metabolism.
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Hajo-Tello, N., Dupont, C., Wepierre, J., Cohen, Y., Miller, R., & Godfraind, T. (1985). Effects of tabernanthine on calcium and catecholamine stimulated contractions of isolated vascular and cardiac muscle. Archives Internationales de Pharmacodynamie, 276(1), 35-43. https://hdl.handle.net/2078.5/130498 (Original work published 1985)