Evidence that mammalian lignans show endogenous digitalis-like activities.
(1986) Biochemical and Biophysical Research Communications — Vol. 134, n° 3, p. 1064-1070 (1986)
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- Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces 3H-ouabain from its binding sites on cardiac digitalis receptor and inhibits, dose dependently, the Na+, K+-ATPase activity of human and guinea-pig heart. The time dependence of this inhibition resembles that of dihydroouabain, a cardiac glycoside in which the lactone ring does not contain conjugated double bonds. The active concentrations of enterolactone as inhibitor of Na+,K+-ATPase are in the 10(-4) M range and, at those concentrations, the cross-reactivity with antidigoxin antibodies is low. Lignans may contribute to the putative digitalis-like activity found in tissues, blood and urine of several mammals including man.
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Fagoo, M., Braquet, P., Robin, J. P., Esanu, A., & Godfraind, T. (1986). Evidence that mammalian lignans show endogenous digitalis-like activities. Biochemical and Biophysical Research Communications, 134(3), 1064-1070. https://hdl.handle.net/2078.5/55347 (Original work published 1986)