Adrenalectomy prevents the development of alcohol preference in male rats
(1996) Alcohol (New York) — Vol. 13, n° 3, p. 233-238 (1996)
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- Abstract
- By forcing adrenalectomized (ADX) and sham-operated (SHAM) rats to chronically drink ethanol by mean of presentation of only one drinking bottle containing 10% ethanol, no differences occurred between both groups. ADX and SHAM rats were then exposed to chronic alcoholization using an inhalation procedure. After sejourning 3 weeks into the alcoholization chamber, rats were submitted to a free-choice paradigm [water vs. a 10% (v/v) ethanol solution]. The sham-operated rats presented an alcohol-induced behavioral preference towards alcohol whereas adrenalectomized animals never exhibited a preference to ethanol. In the adrenalectomized rats treatment with hydrocortisone (30 mu g/ml) given orally during the pulmonary alcoholization failed to modify this preference whereas treatment with corticosterone (25 mu g/ml) given orally abolished the difference with SHAM animals. These data showed that adrenalectomy prevented the development of ethanol preference and the clear involvement of the hypothalamo-pituitary-axis in alcohol preference.
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Lamblin, F., & De Witte, P. (1996). Adrenalectomy prevents the development of alcohol preference in male rats. Alcohol (New York), 13(3), 233-238. https://doi.org/10.1016/0741-8329(95)02043-8 (Original work published 1996)