Virally induced modulation of murine IgG antibody subclasses.
(1988) The Journal of Experimental Medicine — Vol. 168, n° 6, p. 2373-2378 (1988)
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- Authors
Coutelier, Jean-Paul 
- Abstract
- The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.
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Citations
Coutelier, J.-P., van der Logt, J. T., Heessen, F. W., Vink, A., & Van Snick, J. (1988). Virally induced modulation of murine IgG antibody subclasses. The Journal of Experimental Medicine, 168(6), 2373-2378. https://doi.org/10.1084/jem.168.6.2373 (Original work published 1988)