Library of synthetic compounds based on pyrazole unit: Design and screening against breast and colorectal cancer
(2014) Letters in Drug Design & Discovery — Vol. 11, n° 8, p. 1010-1016 (2014)
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- Abstract
- Pyrazolic compounds represent a large source of anticancer compounds, based on the choice of the scaffold structure, the nature of the substituents and the sites of coordination. Here, we discuss our recent progresses in identifying new active molecules from a synthetic library of 14 nitrogen compounds. All these compounds exert antiproliferative activity against breast and colorectal cancer cell lines with varying IC<inf>50</inf> values (the half-maximal inhibitory concentration, which is a measure of the effectiveness of a compound in inhibiting biological or biochemical function). We found a onelog order difference in activity among the different tested compounds. The most active compound 7 showed an IC<inf>50</inf> values equal to 8.5μg/ml in both MDA-MB 231(breast cancer) and LOVO (colorectal cancer) cell lines. © 2014 Bentham Science Publishers.
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Abrigach, F., Khoutoul, M., Benchat, N., Radi, S., Draoui, N., Feron, O., Riant, O., & Touzani, R. (2014). Library of synthetic compounds based on pyrazole unit: Design and screening against breast and colorectal cancer. Letters in Drug Design & Discovery, 11(8), 1010-1016. https://doi.org/10.2174/1570180811666140512220842 (Original work published 2014)