Depression: from psychopathology to pathophysiology
(2015) Current Opinion in Neurobiology — Vol. 30, p. 24-30 (2015)
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- Abstract
- Major depression is a psychiatric disorder with high prevalence. Both specialists in cognitive psychopathology and neurobiologists have proposed explanations of the process/systems that exhibit altered functioning during this disorder. Psychological processes that are dysfunctional in depressed patients include alterations in self-referential schemas, cognitive biases, ruminations and processing mode (over-general versus concrete). These cognitive processes are associated with altered function of specific brain systems, including prefrontal areas and cingulate cortex (both involved in self-referential processes and rumination), amygdala (cognitive bias), lateral habenula (cognitive bias) and hippocampus (cognitive bias and overgeneral processing). This review aims to present a coherent view integrating these two approaches in a unique model.
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Belzung, C., Willner, P., & Philippot, P. (2015). Depression: from psychopathology to pathophysiology. Current Opinion in Neurobiology, 30, 24-30. https://doi.org/10.1016/j.conb.2014.08.013 (Original work published 2015)