Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels.

Douxfils, Jonathan;Vayne, Caroline;Pouplard, Claire;Lecompte, Thomas;Mullier, François;et.al.
(2021) Haematologica — Vol. 106, n° 12, p. 3249-3252 (2021)

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Authors
  • Douxfils, Jonathan
    Author
  • Vayne, Caroline
    Author
  • Pouplard, Claire
    Author
  • Lecompte, Thomas
    Author
  • Potier, FlorenceUCLouvain
    Author
  • Gasser, EmyUCLouvain
    Author
  • Mathieux, ValérieUCLouvain
    Author
  • Mullier, FrançoisUCLouvain
    Author
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Abstract
(en) The present report describes a vaccine-induced thrombotic thrombocytopenia (VITT) case with fatal exacerbation after initial improvement following initial intravenous immunoglobulin (IVIg) administration and anticoagulation. An 83-year-old woman presented at the emergency room with an alteration of her general condition. She presented with symptoms of weakness, nausea, vomiting, weight loss and spontaneous bruises without any obvious reason, 14 days after having received her first dose of ChadOx1 nCov-19. [...]
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Douxfils, J., Vayne, C., Pouplard, C., Lecompte, T., Favresse, J., Potier, F., Gasser, E., Mathieux, V., Dogné, J.-M., Gruel, Y., Rollin, J., & Mullier, F. (2021). Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels. Haematologica, 106(12), 3249-3252. https://doi.org/10.3324/haematol.2021.279509 (Original work published 2021)