Role of AMP-activated protein kinase in sepsis-induced cardiovascular dysfunction.
(2019) American journal of physiology. Heart and circulatory physiology — Vol. 316, n° 4, p. H934-H935 (2019)
Files
ajpheart000152019.pdf
Open Access - Adobe PDF
- 77.84 KB
Details
- Authors
Castanares Zapatero, Diego 
- Abstract
- (en) to the editor: As founding members of a laboratory working on AMP-activated protein kinase (AMPK) for more than 20 yr, we have carried a lot of interest to the recent study regarding the effect of AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) on age-dependent cardiac function during experimental sepsis performed by Inata et al. (4) and highlighted by an Editorial Focus (7). We would like to comment on the proposed hypothesis taking into account data we previously published on the same issue (2). In agreement with Inata et al.’s paper, we also think that AMPK activation has to be considered as a new potential therapeutic approach in sepsis-induced cardiovascular impairment. However, we believe that the protection conferred by AMPK more likely relies on an endothelial action (as endothelial cells mainly express the α1-AMPK isoform) rather than on cardiomyocytes (which mainly express the α2-AMPK isoform). This conclusion is based on data that we already published in Critical Care Medicine in 2013 (2). Our arguments are supported by several observations. [...]
- Affiliations
Citations
Angé, M., Castanares Zapatero, D., Bertrand, L., Horman, S., & Beauloye, C. (2019). Role of AMP-activated protein kinase in sepsis-induced cardiovascular dysfunction. American journal of physiology. Heart and circulatory physiology, 316(4), H934-H935. https://doi.org/10.1152/ajpheart.00015.2019 (Original work published 2019)