Sodium polystyrene sulfonate: still news after 60 years on the market.

Labriola, Laura;Jadoul, Michel
(2020) Nephrology, dialysis, transplantation — Vol. 35, n° 9, p. 1455-1458 (2020)

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Abstract
(en) yperkalaemia is common and potentially life-threatening in multiple clinical settings, especially in chronic kidney disease (CKD). Potassium-binding resins (K resins) have been used for 60 years for the treatment of hyperkalaemia. Sodium polystyrene sulfonate (SPS) is a cross-linked polymer whose reactive sulfonic groups exchange preloaded sodium (Na) for another cation. As a result of the concentrations of Na+ and K+ along the gastrointestinal (GI) lumen, the single favourable site for Na+–K+ exchange is the colon. [...]
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Labriola, L., & Jadoul, M. (2020). Sodium polystyrene sulfonate: still news after 60 years on the market. Nephrology, dialysis, transplantation, 35(9), 1455-1458. https://doi.org/10.1093/ndt/gfaa004 (Original work published 2020)