Parkinson's Disease Home Diary: Further Validation and Implications for Clinical Trials,
(2004) Movement Disorders — Vol. 19, p. 1409-1413 (2004)
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- Authors
Lehert, Philippe 
- Abstract
- (en) We provide further validation of a Parkinson's disease (PD) home diary and explore implications for practical use in clinical trials. We suggested that that on time without dyskinesia or with nontroublesome dyskinesia would be an appropriate outcome measure in clinical trials of advanced PD patients. In the current study, PD patients with motor fluctuations and dyskinesia (present more than 25% of the awake day and at least moderately disabling) completed daily diaries on 3 consecutive days in each of 2 consecutive weeks. In addition, patients provided responses to five questions regarding dyskinesia and their motor response through the day on visual analog scales (VAS). Three hundred two patients from 10 countries participated. Mean percent of the awake day on without dyskinesia or with nontroublesome dyskinesia ( good on , ONG%) was observed to be very stable over time (repeated measure analysis of variance, P = 0.99).
- Affiliations
Louvain School of Management
Citations
Hauser, R., Lehert, P., & Deckers, F. (2004). Parkinson’s Disease Home Diary: Further Validation and Implications for Clinical Trials,. Movement Disorders, 19, 1409-1413. https://doi.org/10.1002/mds.20248 (Original work published 2004)