Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool.
(2011) Gastroenterology — Vol. 141, n° 3, p. 1003-1013 (2011)
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- Authors
- Abstract
- Although Kras/KRAS mutation promotes serrated and hyperplastic morphologic features in colon epithelium, it is not able to initiate adenoma development, perhaps in part because activated Kras/KRAS signaling does not increase the number of presumptive stem cells in affected crypts.
- Affiliations
autre University of Michigan
Citations
Feng, Y., Bommer, G., Zhao, J., Green, M., Sands, E., Zhai, Y., Brown, K., Burberry, A., Cho, K. R., & Fearon, E. R. (2011). Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. Gastroenterology, 141(3), 1003-1013. https://doi.org/10.1053/j.gastro.2011.05.007 (Original work published 2011)