Cell wall mutants for delivery of biologically active compounds
(2003)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- The present invention relates to a recombinant microorganism comprising a mutation modulating the expression of a gene involved in the biosynthesis, modification or degradation of a cell wall component or expressing a foreign gene interfering with the biosynthesis, modification or degradation of a cell wall component and comprising an expression vector leading to the production of a polypeptide having a prophylactic or therapeutic activity.The invention further relates to a method for the delivery of polypeptides at mucosal surfaces, comprising administering to a mucosal surface of an individual (human or animal) a composition comprising a recombinant microorganism comprising a mutation modulating the expression of a gene involved in the biosynthesis, modification or degradation of a cell wall component or expressing a foreign gene interfering with the biosynthesis, modification or degradation of a cell wall component and wherein the polypeptide to be delivered is produced by said recombinant microorganism.
Citations
Grangette, C., Mercenier, A., Delcour, J., & Hols, P. (2003). Cell wall mutants for delivery of biologically active compounds. https://hdl.handle.net/2078.5/255396