Antimalarial activity of cryptolepine and some other anhydronium bases
(1996) Phytotherapy Research : an international journal devoted to medical and scientific research on plants and plant products — Vol. 10, n° 4, p. 361-363 (1996)
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- Abstract
- Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day.
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Wright, C. W., Philipson, J. D., Awe, S. O., Kirby, G. C., Warhurst, D. C., Quetin-Leclercq, J., & Angenot, L. (1996). Antimalarial activity of cryptolepine and some other anhydronium bases. Phytotherapy Research : an international journal devoted to medical and scientific research on plants and plant products, 10(4), 361-363. https://doi.org/10.1002/(SICI)1099-1573(199606)10:4<361::AID-PTR845>3.0.CO;2-N (Original work published 1996)