Platelet function in the context of global hemostasis : a comprehensive study in patients with cirrhosis
(2025)
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- Authors
- Supervisors
- Stephenne, Xavier
- Abstract
- The hemostatic system in patients with cirrhosis is complex with alterations in pro-hemostatic and anti-hemostatic drivers leading to so-called rebalanced hemostasis. Literature on the hemostatic system in pediatric cirrhosis is limited, particularly regarding primary hemostasis. To address this gap, we conducted a proof-of-principle study to inform future, clinically focused research. We investigated the hemostatic system—including primary hemostasis, the coagulation cascade, and fibrinolysis — in a cohort of pediatric patients with cirrhosis, just before and 3 months after living donor liver transplantation. Primary hemostasis was assessed using both flow cytometry and a dynamic microfluidic assay. Overall, pediatric patients with cirrhosis displayed a relatively rebalanced hemostatic system before liver transplantation, with primary hemostasis varying according to platelet count, von Willebrand factor levels, and disease severity.
- Affiliations
Citations
van Dievoet, M.-A. (2025). Platelet function in the context of global hemostasis : a comprehensive study in patients with cirrhosis. https://hdl.handle.net/2078.5/272835