A comparison of the P300 and PET in patients with disorders of consciousness in absence of response to command
(2018) European Academy of Neurology — Location: Lisbon, Portugal (16.June.2018)
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- Abstract
- Detection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish "covert command following." These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed "covert command following" (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without "covert command-following" but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe "covert command following" in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC
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Citations
Annen, J., Wolff, A., Blandiaux, S., Lejeune, N., Chatelle, C., & Laureys, S. (2018). A comparison of the P300 and PET in patients with disorders of consciousness in absence of response to command. European Academy of Neurology, Lisbon, Portugal. https://hdl.handle.net/2078.5/89098