"Clip" and "click" chemistries combination: toward easy PEGylation of degradable aliphatic polyesters
(2011) Macromolecular Rapid Communications — Vol. 32, n° 7, p. 616-621 (2011)
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- Authors
- Abstract
- a-Methoxy-v-alkyne poly(ethylene glycol) (PEG) was tagged with pendent N-hydroxy-succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen’s 1,3- dipolar cycloaddition. This original combination of ‘‘clip’’ and ‘‘click’’ reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug-delivery.
- Affiliations
University of Liège Center for Education and Research on Macromolecules (CERM)
Citations
Freichels, H., Pourcelle, V., Le Duff, C. S., Marchand-Brynaert, J., & Jérôme, C. (2011). “Clip” and “click” chemistries combination: toward easy PEGylation of degradable aliphatic polyesters. Macromolecular Rapid Communications, 32(7), 616-621. https://doi.org/10.1002/marc.201000803 (Original work published 2011)