Two-step transplantation for primary hyperoxaluria: Cadaveric liver followed by living donor related kidney transplantation
(2008) Pediatric Transplantation — Vol. 13, n° 6, p. 782-784 (2009)
Files
20026.pdf
Restricted Access - Adobe PDF
- 63.19 KB
Details
- Authors
- Abstract
- Malla I, Lysy PA, Godefroid N, Smets F, Malaise J, Reding R, Sokal EM. Two-step transplantation for primary hyperoxaluria: Cadaveric liver followed by living donor related kidney transplantation. Pediatr Transplantation 2008. (c) 2008 Wiley Periodicals, Inc.Abstract: In PH, PLTX, although ideal in theory, is rarely achieved. Patients usually have reached end-stage kidney disease while requiring combined liver and kidney transplantation. In this combined procedure, the sudden high oxalates mobilization from blood and tissue stores jeopardizes the success of the kidney graft, with a high risk of post-transplant early kidney necrosis or chronic graft damage. Here, we report the case of a three-yr-old girl with PH and ESRF in whom we performed sequentially deceased donor liver transplantation followed four months later by living donor kidney transplant, after normalization of blood oxalate levels and improvement of urinary oxalate output. After this two-step transplantation, our patient showed normalization of renal function with good urinary output and maintained normal blood oxalate levels. This strategy seems to be a reasonable approach in order to avoid acute renal tubular injury because of oxalate excretion in these patients.
- Affiliations
Citations
Malla, I., Lysy, P., Godefroid, N., Smets, F., Malaise, J., Reding, R., & Sokal, E. (2008). Two-step transplantation for primary hyperoxaluria: Cadaveric liver followed by living donor related kidney transplantation. Pediatric Transplantation, 13(6), 782-784. https://doi.org/10.1111/j.1399-3046.2008.01049.x (Original work published 2009)