Identification of a MAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-B*5701 tumors
(2004) Tissue Antigens : immune response genetics — Vol. 63, n° 5, p. 453-457 (2004)
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- Abstract
- 'Cancer germline' genes such as those of the MAGE family are expressed in many tumors and in male germline cells but are silent in normal tissues. They encode shared tumor-specific antigens that have been used in therapeutic vaccination trials of cancer patients. We report the identification of a new MAGE-1-encoded peptide that is recognized by a cytolytic T-lymphocyte (CTL) clone on human leukocyte antigen (HLA)-B*5701. The sequence of the peptide, corresponding to position 102-112 of the MAGE-1 protein sequence, is ITYKVADLVGF. When tumor cells expressing MAGE-1 were transfected with HLA-B*5701, they were lyzed by the CTL clone, indicating that the peptide is processed in tumor cells and can, therefore, be used as a target for anti-tumoral vaccination.
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Citations
Corbiere, V., Nicolay, H., Russo, V., Stroobant, V., Brichard, V., Boon, T., & van der Bruggen, P. (2004). Identification of a MAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-B*5701 tumors. Tissue Antigens : immune response genetics, 63(5), 453-457. https://doi.org/10.1111/j.0001-2815.2004.00203.x (Original work published 2004)