We studied the nycterohemeral variations of homovanillic acid (HVA) in ventricular cerebrospinal fluid (CSF) in 24 patients undergoing monitoring of intracranial pressure as part of the normotensive hydrocephalus (NTH) work-up. CSF samples were obtained every 4 h in each patient. The mean individual values of HVA in the ventricular CSF ranged from 133 to 421 ng/ml, and they could not be correlated to any clinical feature. The intraindividual levels of HVA were stable throughout 24 hours, with a variation coefficient inferior to 10% in 63% of cases, and inferior to 20% in all the patients.
Hildebrand, J., Moussa, Z., Raftopoulos, C., Vanhouche, J., Laute, M. A., & Przedborski, S. (1992). Variations of homovanillic acid levels in ventricular cerebrospinal fluid. Acta Neurologica Scandinavica, 85(5), 340-342. https://hdl.handle.net/2078.5/65851 (Original work published 1992)