IL-9 receptor signaling in memory B cells regulates humoral recall responses.
(2018) Nature Immunology — Vol. 19, n° 9, p. 1025-1034 (2018)
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Kitamura, Daisuke 
- Abstract
- Memory B cells (B cells) are the basis of long-lasting humoral immunity. They respond to re-encountered antigens by rapidly producing specific antibodies and forming germinal centers (GCs), a recall response that has been known for decades but remains poorly understood. We found that the receptor for the cytokine IL-9 (IL-9R) was induced selectively on B cells after primary immunization and that IL-9R-deficient mice exhibited a normal primary antibody response but impaired recall antibody responses, with attenuated population expansion and plasma-cell differentiation of B cells. In contrast, there was augmented GC formation, possibly due to defective downregulation of the ligand for the co-stimulatory receptor ICOS on B cells. A fraction of B cells produced IL-9. These findings indicate that IL-9R signaling in B cells regulates humoral recall responses.
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Citations
Takatsuka, S., Yamada, H., Haniuda, K., Saruwatari, H., Ichihashi, M., Renauld, J.-C., & Kitamura, D. (2018). IL-9 receptor signaling in memory B cells regulates humoral recall responses. Nature Immunology, 19(9), 1025-1034. https://doi.org/10.1038/s41590-018-0177-0 (Original work published 2018)