Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide
(2018) Journal of Colloid and Interface Science — Vol. 532, p. 112-117 (2018)
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- Abstract
- Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water.
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Citations
Parilti, R., Caprasse, J., Riva, R., Alexandre, M., Vandegaart, H., Bebrone, C., Dupont, C., Howdle, S. M., & Jérôme, C. (2018). Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide. Journal of Colloid and Interface Science, 532, 112-117. https://doi.org/10.1016/j.jcis.2018.07.125 (Original work published 2018)