Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction
(1998) Addiction Biology — Vol. 3, n° 4, p. 465-472 (1998)
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- The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of pushing in all groups, suggesting that a specific gene defect might be involved Our previous investigations had inferred normal ALDH, in such affected individuals, but low activities of erythrocyte ALDH(1).(1) Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH(3)(1) and ADH(3)(2) showed a higher frequency for ADH(3)(1), 58%, than ADH(3)(2), 42%. This is comparable to the Caucasian controls and to our previously published data.
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Ward, R. J., McCradden, J., Tipton, K., Sherwood, R., Keating, J., Peters, TJ., & De Witte, P. (1998). Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction. Addiction Biology, 3(4), 465-472. https://doi.org/10.1080/13556219872010 (Original work published 1998)