The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
(1997) FEBS Letters — Vol. 409, n° 3, p. 325-332 (1997)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 242 KB
Details
- Authors
- Abstract
- A total of sixteen open reading frames encoding for P-type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae. Phylogenetic analysis distinguishes 6 distinct families. Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H+ (2 members), Ca2+ (2 members), Na+ (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members). It is proposed that the latter family which has homologs in Tetrahymena thermophila, Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4-ATPases with characteristic topology and aminoacid signatures.
- Affiliations
Citations
Catty, P., de Kerchove d’Exaerde, A., & Goffeau, A. (1997). The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Letters, 409(3), 325-332. https://doi.org/10.1016/S0014-5793(97)00446-8 (Original work published 1997)