Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer disease, but it seems insufficiently sensitive for the aMCI stage. We postulated that some hippocampus subfields are specifically atrophic in aMCI and that measuring hippocampus subfield volumes will improve sensitivity of MR imaging to detect aMCI.
Hanseeuw, B., Van Leemput, K., Kavec, M., Grandin, C., Seron, X., & Ivanoiu, A. (2011). Mild cognitive impairment : differential atrophy in the hippocampal subfields. American Journal of Neuroradiology, 32(9), 1658-1661. https://doi.org/10.3174/ajnr.A2589 (Original work published 2011)