Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1-11 years
(2010) Vaccine — Vol. 28, n° 27, p. 4411-4415 (2010)
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- Authors
Sokal, Etienne 
- Abstract
- (en) This study compared the long-term persistence of anti-hepatitis A (anti-HAV) and B (anti-HBs) antibodies, 5 years after vaccination of subjects aged 1-11 years with a combined hepatitis A and B vaccine either in a two-dose (0, 6 months, Adult formulation) or a three-dose (0, 1, 6 months, Paediatric formulation) schedule. At the end of the 5 years, all subjects (100%) in both groups continued to have anti-HAV antibodies >= 15 mIU/mL, while 94-97% of subjects in both groups had anti-HBs antibody concentrations >= 10 mIU/mL Subjects with anti-HBs antibody concentration <= 10 mIU/mL were administered a challenge dose of hepatitis B vaccine. All subjects mounted a vigorous immune response to the challenge indicating the presence of immunological memory to HBV. (C) 2010 Published by Elsevier Ltd.
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Citations
Marshall, H., Nolan, T., Diez Domingo, J., Rombo, L., Sokal, E., Mares, J., Casanovas, J. M., Kuriyakoss, S., Leyssen, M., & Jacquet, J.-M. (2010). Long-term (5-year) antibody persistence following two- and three-dose regimens of a combined hepatitis A and B vaccine in children aged 1-11 years. Vaccine, 28(27), 4411-4415. https://doi.org/10.1016/j.vaccine.2010.04.040 (Original work published 2010)