Diagnostic value and clinical implications of anti-P0 antibodies in autoimmune inner ear disease
(2002)
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- The aim of this study was to develop a method for the measurement of antibodies directed against cochlear antigens in autoimmune inner ear disease (AIED). We especially investigated the nature of the antigens, the specificity of the test and the clinical significance of the antibodies. <BR> the first part of the thesis describes the development and optimisation of an immunoblot method for detection of anti-cochlear antibodies against a 30000-Mr, protein than healthy blood donors. <BR> In the second part of the thesis, we show that the 30000-Mr, antigen is the major peripheral myelin protein P0. <BR> The third part of the thesis describes a longitudinal study of patients with idiopathic sensorineural hearing loss (SNHL), where the association of circulating anti-0 antibodies and the clinical course was investigated. Our results indicate that idiopathic SNHL, assessed by the presence of anti-P0 antibodies, is more frequently associated with progressive than with sudden hearing loss. Furthermore, patients with anti-P0 antibodies in children and young adults. The study shows that the prevalence of antibodies against protein P0 in normally hearing individuals is about 1%. This suggest that the presence of anti-P0 antibodies is pathognomomic
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Tomasi, J.-P. (2002). Diagnostic value and clinical implications of anti-P0 antibodies in autoimmune inner ear disease. https://hdl.handle.net/2078.5/110899