Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

Marquer, Catherine;Laine, Jeanne;Dauphinot, Luce;Hanbouch, Linda;Potier, Marie-Claude;et.al.
(2014) Molecular Neurodegeneration — Vol. 9, n° 1, p. 60 (2014)

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Authors
  • Marquer, Catherine
    Author
  • Laine, Jeanne
    Author
  • Dauphinot, Luce
    Author
  • Hanbouch, Linda
    Author
  • Pierrot, NathalieUCLouvain
    Author
  • Octave, Jean-NoëlUCLouvain
    Author
  • Potier, Marie-Claude
    Author
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Abstract
It is suspected that excess of brain cholesterol plays a role in Alzheimer's disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to correlate with the severity of the disease. We hypothesized that an increase of membrane cholesterol could trigger sporadic AD early phenotypes.
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Marquer, C., Laine, J., Dauphinot, L., Hanbouch, L., Lemercier-Neuillet, C., Pierrot, N., Bossers, K., Le, M., Corlier, F., Benstaali, C., Saudou, F., Thinakaran, G., Cartier, N., Octave, J.-N., Duyckaerts, C., & Potier, M.-C. (2014). Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes. Molecular Neurodegeneration, 9(1), 60. https://doi.org/10.1186/1750-1326-9-60 (Original work published 2014)