Solvent selection as a major determinant of chiral resolution outcomes: the BINOL–DACH case study

de Meester, Joséphine;Shemchuk, Oleksii;Collard, Laurent;Wouters, Johan;Leyssens, Tom;et.al.
(2025) CrystEngComm — Vol. 27, n° 48, p. 7826-7833 (2025)

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Abstract
In this work, we undertook an in-depth study of the combination of two chiral molecules: 1,1′-Bi-2-naphtol (BINOL) and trans-cyclohexane-1,2-diamine (DACH). While exploring various solvents for developing resolution processes, we revealed a multitude of solid phases. Here is analyzed the different crystalline forms obtained in the selected solvents, underscoring the critical importance of the solvent choice for the development of a chiral resolution process.
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de Meester, J., Shemchuk, O., Collard, L., Wouters, J., Robeyns, K., & Leyssens, T. (2025). Solvent selection as a major determinant of chiral resolution outcomes: the BINOL–DACH case study. CrystEngComm, 27(48), 7826-7833. https://doi.org/10.1039/d5ce00706b (Original work published 2025)