Starvation or diabetes decreases the content but not the mRNA of 6-phosphofructo-2-kinase in rat liver.
(1988) FEBS Letters — Vol. 227, n° 2, p. 136-140 (1988)
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- Abstract
- In rat liver, the activity of 6-phosphofructo-2-kinase (PFK-2) decreases upon starvation and in diabetes. Cyclic AMP-dependent phosphorylation of the enzyme is not sufficient to account for this decrease. PFK-2 content was therefore measured by immunotitration and relative PFK-2 mRNA levels were determined by hybridization with cDNA probes. The data are compatible with a posttranscriptional mechanism of regulation that involves decreased translational efficiency of PFK-2 mRNA and (or) increased turnover of the PFK-2 protein.
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Crepin, K. M., Darville, M. I., Hue, L., & Rousseau, G. (1988). Starvation or diabetes decreases the content but not the mRNA of 6-phosphofructo-2-kinase in rat liver. FEBS Letters, 227(2), 136-140. https://doi.org/10.1016/0014-5793(88)80884-6 (Original work published 1988)