Role of presenilin transmembrane domain interactions in gamma-secretase activity and characterization of natural inhibitors
(2014)
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- Authors
- Supervisors
- Kienlen-Campard, Pascal
- Abstract
- Alzheimer’s disease (AD) represents 60-80% of all dementia. As this disease has an important economic and social impact, many scientific efforts aim to understand the fine mechanisms behind this disease, and to find effective treatments. In Alzheimer’s disease gamma-secretase complex and amyloid precursor protein (APP) are central players, with the first being responsible for the Abeta peptides production and the latter harboring the Abeta sequence. Understanding the mechanisms controlling the functionality of gamma-secretase represents a fundamental tool to gain access to the disease. This thesis work focuses on gamma-secretase, and in particular it aims to understand the role of specific structural determinants we identified in the catalytic core of this enzyme, known as Presenilin, and to better characterize the inhibitory effects of specific plant extracts on the activity of gamma-secretase
- Affiliations
Citations
Marinangeli, C. (2014). Role of presenilin transmembrane domain interactions in gamma-secretase activity and characterization of natural inhibitors. https://hdl.handle.net/2078.5/193300