First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids
(2014) Fertility and Sterility — Vol. 102, n° 5, p. 1404-1409 (2014)
Files
Firstseriesof18MLFS.pdf
Open Access - Adobe PDF
- 659.81 KB
Details
- Authors
- Abstract
- OBJECTIVE: To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids. DESIGN: Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials. SETTING: Academic hospital. PATIENT(S): Among the 52 patients, 21 wished to conceive upon treatment completion. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pregnancy rate and live birth rate. RESULT(S): Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy. CONCLUSION(S): We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.
- Affiliations
Citations
Luyckx, M., Squifflet, J.-L., Jadoul, P., Votino, R., Dolmans, M.-M., & Donnez, J. (2014). First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids. Fertility and Sterility, 102(5), 1404-1409. https://doi.org/10.1016/j.fertnstert.2014.07.1253 (Original work published 2014)