Réactions de cyclisation radicalaire et de couplage croisé catalysées par des complexes de fer
(2010)
Files
ibergiers.pdf
Open Access - Adobe PDF
- 1.62 MB
Details
- Authors
- Supervisors
- Riant, Olivier
- Abstract
- (en) Iron-catalyzed cross-coupling reactions have known a huge development these last years due to their exceptional efficiency. These complexes can promote the cross-coupling reaction between organic halides and Grignard reagents in a matter of few minutes. The studies reported in the literature show that radical species are probably implied in the reaction mechanism, at least in certain cases. In this work, we were interested in the development of a catalytic system, based on the use of iron complexes to induce a radical cyclization followed by a cross-coupling reaction. Similarly to catalytic systems of cross-coupling reactions reported in the literature, Grignard reagents were used as nucleophiles. The system showed very interesting activities, as total conversions were obtained in a matter of few minutes at room temperature. Then, we tried other organometallic reagents as nucleophiles, notably alanes, which gave good results in terms of chemoselectivity.
- Affiliations
Citations
Bergiers, I. (2010). Réactions de cyclisation radicalaire et de couplage croisé catalysées par des complexes de fer. https://hdl.handle.net/2078.5/131141