Circulating bioactive inhibin levels during human pregnancy.
(1991) Journal of Clinical Endocrinology and Metabolism — Vol. 72, n° 4, p. 862-866 (1991)
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- In this study bioactive inhibin was measured in 112 serum samples from 103 pregnant women by a sensitive ovine pituitary cell culture system. Human inhibin activities were detected in a range between 0.02-5.28 U/mL at six dilutions by using serum from the 38-week pregnant women as a quality control. A remarkable increase in serum inhibin was observed from 4 to 38 weeks of pregnancy. The mean serum inhibin level was 1.58 U/mL at 4 weeks. Thereafter, inhibin levels increased progressively with the weeks of pregnancy (r = 0.988; P less than 0.001). In the midterm of pregnancy, serum inhibin was elevated at average levels of 2.84 and 3.84 U/mL at 20 and 28 weeks, respectively. The peak level of inhibin (5.33 U/mL) was obtained at 38 weeks, which was an increase of 237% compared to that at 4 weeks. The average rate of increase in serum inhibin levels was 14.51% every 2-4 weeks (ranging from 8.1-20%). These findings suggest that circulating inhibin is useful marker during human pregnancy.
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Qu, J. P., Vankrieken, L., Brulet, C., & Thomas, K. (1991). Circulating bioactive inhibin levels during human pregnancy. Journal of Clinical Endocrinology and Metabolism, 72(4), 862-866. https://doi.org/10.1210/jcem-72-4-862 (Original work published 1991)